Quality-Control Mechanism for Telomerase RNA Folding in the Cell
نویسندگان
چکیده
منابع مشابه
Biphasic folding kinetics of RNA pseudoknots and telomerase RNA activity.
Using a combined master equation and kinetic cluster approach, we investigate RNA pseudoknot folding and unfolding kinetics. The energetic parameters are computed from a recently developed Vfold model for RNA secondary structure and pseudoknot folding thermodynamics. The folding kinetics theory is based on the complete conformational ensemble, including all the native-like and non-native states...
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15 صفحه اولTelomerase RNA: A Flexible RNA Scaffold for Telomerase Biosynthesis
Determination of the structure of the yeast telomerase RNA component TLC1 has been hampered by its large size and high rate of evolutionary divergence. But detailed phylogenetic comparisons have now revealed the unusually flexible and modular architecture of this important RNA molecule.
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ژورنال
عنوان ژورنال: Cell Reports
سال: 2020
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2020.108568